INTRANASAL DELIVERY OF A CHIMPANZEE ADENOVIRUS VECTOR EXPRESSING A PRE-FUSION SPIKE (BV-ADCOV-1) PROTECTS GOLDEN SYRIAN HAMSTERS AGAINST SARS-COV-2 INFECTION

We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.Intranasal administration of BV-AdCoV-1 elicited strong humoral and cellular immunity in the animals.Furthermore, va

The outflow of freshwater from underwater channels in the Kongsbreen tidal glacier in Kongsfjorden, Svalbard, 79oN, was measured as 138.8 m3 s-1 at the peak of the melting season.Experiments on local marine plankton mortality show that when exposed to salinities below 9 PSU, all copepods die within 15 minutes.We estimate that during 100 days of the

Abstract Microglia are involved in neuroinflammatory processes during diverse pathophysiological conditions.To date, the possible contribution of these cells to deoxynivalenol (DON)-induced brain inflammation and anorexia has not yet been evaluated.DON, one of the most abundant trichothecenes found in cereals, has been implicated in mycotoxicosis S

Over the past 4 years, cancer immunotherapy has significantly prolonged survival Marble Dining Table time of patients with prostate cancer, melanoma, lung cancer, and liver cancer, but its side effects are also impressive.Different types of the immune therapeutic agents have different on-target or off-target toxicity due to high affinity or weak sp

Haemophilia-A is characterized by deficiency of FVIII, but the bleeding diathesis is not a mere reflection low FVIII activity.The pathophysiology of haemophilic bleeding diathesis is a complex interplay between defective procoagulant function and up-regulated fibrinolysis.Moreover, haemophilic bleeding diathesis is frequently compounded by treatmen